研究・実績Research ・ achievements


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1.Korogi W, Yoshizawa T, Karim Md, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K.
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Biochemical and Biophysical Research Communications 496 (3): 891-897, 2018

2.Sueta D, Kaikita K, Okamoto N, Yamabe S, Ishii M, Arima Y, Ito M, Oimatsu Y, Mitsuse T, Iwashita S, Nakamura E, Hokimoto S, Mizuta H, Ogawa H, Tsujita K.
Edoxaban Enhances Thromboprophylaxis by Physiotherapy After Total Knee Arthroplasty - The Randomized Controlled ESCORT-TKA Trial.
Circ J 82(2):524-531, 2018

3.Hisanaga S, Miyake M, Taniuchi S, Oyadomari M, Morimoto M, Sato R, Hirose J, Mizuta H, Oyadomari S.
PERK-mediated translational control is required for collagen secretion in chondrocytes.
Scientific reports 8(1):773, 2018

4.Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y.
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as acartilage matrix factor.
Osteoarthritis Cartilage 26(1):108-117, 2018

5.Ide J, Tokunaga T.
Rotator cuff tendon-to-bone healing at 12 months after patch grafting of acellular dermal matrix in an animal model.
Journal of Orthopaedic Science 23;207-212, 2018

6.Itoh H, Kadomatsu T, Tanoue H, Yugami M, Miyata K, Endo M, Morinaga J, Kobayashi E, Miyamoto T, Kurahashi R, Terada K, Mizuta H,Oike Y.
TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.
ONCOGENE 37(22):2903-2920, 2018

7.Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
CD163 is involved in the protumour activation of macrophages in human and murine sarcoma.
Cancer Research 78(12):3255-3266, 2018


1. Tsukamoto H., Fujieda K., Hirayama M., Yuno A., Ikeda T., Matsumura K., Fukuma D., Araki K., Mizuta H., Nakayama H., Senju S., and Nishimura,Y.
Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentiation and drives tumor progression. (*equally contributed author).
Cancer Res 77(9):2279-2291, 2017

2.Arimura H., Shukunami C., Tokunaga T., Karasugi T., Okamoto N., Taniwaki T., Sakamoto H., Mizuta H., Hiraki Y.
TGF-β1 Improves the Biomechanical Strength by Extracellular Matrix Accumulation without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model.
The American Journal of Sports Medicine, 45(10):2394-2404, 2017

3.Tokunaga T., Karasugi T., Arimura H., Yonemitsu R., Sakamoto H., Ide J.,
Mizuta H.
Enhancement of rotator cuff tendon-bone healing with FGF-2 impregnated in gelatin hydrogel sheets in a rabbit model.
Journal of Shoulder and Elbow Surgery 26(10):1708-1717, 2017

4.Onodera J., Yasuda K., Masuda T., Tanabe Y., Kitamura N., Yagi T., Kondo E.

Is the grafted tendon shifted anteriorly in the femoral tunnel at the post-remodeling phase after anterior cruciate ligament reconstruction? A clinical MRI study.
Orthopaedic Journal of Sports Medicine 5(6):online, 2017

5.Ide J., Mochizuki Y., Arthur van Noort., Ochi H., Sridharan S., Itoi E., Greiner S.
Local rhBMP-12 on an absorbable collagen sponge as adjuvant therapy for rotator cuff repair: A phase 1, randomized, standard of care control, multicenter study. Part 2: A pilot study of functional recovery and structural outcome.
Orthopaedic Journal of Sports Medicine 5(9):online, 2017

6.Hirose J, Nagata T, Ogushi M, Okamoto N, Taniwaki T, Oka K, Togami-Tomiguchi W, Koga H, Hayashi K, Usuku K, and Mizuta H.
Validation of Each Category of Kihon Checklist for Assessing Physical Functioning, Nutrition and Cognitive Status in a Community-Dwelling Older Japanese Cohort.
Epidemiology (Sunnyvale) 7 (5): 1-15, 2017.

7.Tokunaga T, Karasugi T, Arimura H, Yonemitsu R, Sakamoto H, Ide J, Mizuta H.
Enhancement of rotator cuff tendon-bone healing with FGF-2 impregnated in gelatin hydrogel sheets in a rabbit model.
Journal of Shoulder and Elbow Surgery 26(10):1708-1717, 2017.

8.Miyake M, Kuroda M, Kiyonari H, Takehana K, Hisanaga S, Morimoto M, Zhang J, Oyadomari M, Sakaue H, Oyadomari S.
Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice.
PLoS One. 12(6):e0179955, 2017.

9.Nakamura E.
Importance of a Dynamic Evaluation of Tibial Osteotomy for Medial Knee Osteoarthritis.
Clinics in Surgery. 2: 1832, 2017.


1. Yanagisawa A, Ueda M, Sueyoshi T, Nakamura E, Tasaki M, Suenaga G, Motokawa H, Toyoshima R, Kinoshita Y, Misumi Y, Yamashita T, Sakaguchi M, Westermark P, Mizuta H, Ando Y.
Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloidAmyloid.
Amyloid;23(1):26-32. 2016

2. Tasaki M, Ueda M, Obayashi K, Motokawa H, Kinoshita Y, Suenaga G, Yanagisawa A, Toyoshima R, Misumi Y, Masuda T, Yamashita T, Ando Y.
Rapid detection of wild-type and mutated transthyretins.
Annals of Clinical Biochemistry 53(Pt 4):508-510, 2016

3. Nishioka H., Nakamura E., Hirose J., Okamoto N., Yamabe S., Mizuta H..
T1ρ and T2 Mapping for the Assessment of Articular Cartilage Changes in Patients With Medial Knee Osteoarthritis After Hemicallotasis Osteotomy..
Bone Joint Research 5(7):294-300, 2016

4. Komohara Y, Fujiwara Y, Ohnishi K, Shiraishi D, Takeya M.
Contribution of Macrophage Polarization to Metabolic Diseases.
Journal of Atherosclerosis and Thrombosis 23(1): 10-17, 2016.

5. Kikukawa K., Ide J., Terakawa Y., Takada K., Morita M., Hashimoto K., Mizuta H.
Hypertrophic teres minor restores shoulder strength and range of external rotation in postero ?superior rotator cuff tears.
Journal of Shoulder and Elbow Surgery 25(11):1882-1888, 2016

6. Yugami M., Odagiri H.(共同筆頭著者), Endo M., Tsutsuki H., Fujii S., Kadomatsu T., Masuda T., Miyata K., Terada K., Tanoue H., Ito H., Morinaga J., Horiguchi H., Sugizaki T., Akaike T., Gotoh T., Takai T., Sawa T., Mizuta H., Oike Y.
Mice deficient in Angiopoietin-like protein2(Angptl2) gene show increased susceptibility to bacterial infection due to attenuated macrophage activity.
Journal of Biological Chemistry 291(36):18843-52, 2016

7. Nakamura E., Okamoto N., Yamabe S., Nishioka H., Mizuta H.
An open-wedge osteotomy of the proximal tibia with hemicallotasis?Technique and outcome.
Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology 6:67-68, 2016

8. Nishioka H., Nakamura E., Hirose J., Okamoto N., Yamabe S., Mizuta H.
MRI T1ρ and T2 mapping for the assessment of articular cartilage changes in patients with medial knee osteoarthritis after hemicallotasis osteotomy
Bone Joint Research 5(7):294-300, 2016

9. Nakano T., Kuwabara A., Mizuta H., Tanaka K.
Contribution of hypoalbuminemia and decreased renal function to the increased mortality after newly diagnosed vertebral fracture in Japanese subjects.
Asia Pacific journal of clinical nutrition 25(3):472-477, 2016

10. Karasugi T., Ide J., Kitamura T., Okamoto N., Tokunaga T., Mizuta H.
Neuropathic pain in patients with rotator cuff tears.
BMC musculoskeletal disorders 17(1):451, 2016

11. Fujiwara Y., Horlad H., Shiraishi D., Tsuboki J., Kudo R., Ikeda T., Nohara T., Takeya M., Komohara Y.
Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.
Molecular Nutrition & Food Research 60(11): 2467-2480, 2016

12. Tsuboki J., Fujiwara Y., Horlad H., Shiraishi D., Nohara T., Tayama S., Motohara T., Saito Y., Ikeda T., Takaishi K., Tashiro H., Yonemoto Y., Katabuchi H., Takeya M., Komohara Y.
Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.
Scientific Reports 6: 29588, 2016.

13. Imamura Y., Haruta M., Tomita Y., Matsumura K., Ikeda T., Yuno A., Hirayama M., Nakayama H., Mizuta H., Nishimura Y., Senju S.
Generation of Large Numbers of Antigen-Expressing Human Dendritic Cells Using CD14-ML Technology.
PLoS One 6:11(4):e0152384, 2016.

14. Yoshida A., Jinnouchi H., Sugiyama S., Hirose J., Segata T., Furuta K.,
Katahira K., Kajiwara K., Hieshima K., Jinnouchi T., Usuku K.

Combined arteriosclerotic assessment of ankle-brachial index and maximum intima-media thickness via CCTA is useful for predicting coronary artery stenosis in patients with type 2 diabetes.
Diabetes Res Clin Pract 117:91-99, 2016.

15. Sueta D., Kaikita K., Okamoto N., Yamabe S., Ishii M., Arima Y., Ito M., Oimatsu Y., Iwashita S., Takahashi A., Sakamoto K., Tsujita K., Nakamura E., Hokimoto S., Mizuta H., Ogawa H.

Efficacy Study of the COmbination of Edoxaban and Physiotherapy on the PRevention of Venous-Thromboembolism in patients after Total Knee Arthroplasty (ESCORT-TKA Trial): Study protocol for a randomized controlled trial.
Clinical Trials and Regulatory Science in Cardiology 19:1-4, 2016


1. Togami W., Sei A., Okada T., Taniwaki T., Fujimoto T, Tahata S., Nagamura K., Nakanishi Y., Mizuta H.
Effects of the water-holding capability of polyvinyl formal sponges on osteogenic ability in in vivo experiments.
Journal of Biomedical Materials Resarch: Part B- Applied Biomaterials 103(1):188-194, 2015

2. Yanagisawa A., Ueda M., Sueyoshi T., Fujimoto T., Ogi Y., Kitagawa K., Tasaki M., Misumi Y., Oshima T., Jono H., Obayashi K., Hirakawa K., Uchida H., Westermark P., Ando Y., Mizuta H.
Amyloid deposits derived from transthyretin in the ligamentum flavom as related to lumbar spinal canal stenosis.
Modern Pathology 28(2):201-207, 2015

3. Nishioka H., Hirose J., Okamoto N., Okada T., Oka K., Taniwaki T., Nakamura E., Yamashita Y., Mizuta H.
Evaluation of the relationship between T1ρ and T2 values and patella cartilage degeneration in patients of the same age group.
European Journal of Radiology 84(3):463-468, 2015

4. Fujimoto T., Taniwaki T., Tahata S., Nakamura T., Mizuta H.
Patient Outcomes for a Minimally Invasive Approach to Treat Lumbar Spinal Canal Stenosis: Is Microendoscopic or Microscopic Decompressive Laminotomy the less invasive surgery?
Clinical Neurology and Neurosurgery 131:21-25, 2015

5. Masuda T., Endo M., Yamamoto Y., Odagiri H., Kadomatsu T., Nakamura T., Tanoue H., Ito H., Yugami M., Miyata K., Morinaga J., Horiguchi H., Moyokawa I., Terada K., Morioka M., Manabe I.,
Iwase H., Mizuta H., and Oike Y.
ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.
Scientific Reports 5:9170, 2015

6. Greiner S., Ide J,, Van Noort A, Mochizuki Y, Ochi H, Marraffino S, Sridharan S,
Rudicel S, Itoi E.
Local rhBMP-12 on an absorbable collagen sponge as an adjuvant therapy for rotator cuff repair. A phase 1, randomized, standard of care control, multicenter study. Part A: Safety and feasibility.
Am J Sports Med 43(8):1994-2004, 2015

7. Tokunaga T., Ide J., Arimura H., Nakamura T., Uehara Y., Sakamoto H., Mizuta H.
The local application of gelatin hydrogel sheets impregnated with platelet-derived growth factor-BB promotes tendon-to-bone healing after rotator cuff repair in rats, Arthroscopy.
The Journal of Arthroscopic and Related Surgery 31(8):1482-1491, 2015


1. Hirose J., Taniwaki T., Fujimoto T., Okada T., Nakamura T., Okamoto N., Usuku K., Mizuta H.
Predictive value of E-PASS and POSSUM systems for postoperative risk assessment of spinal surgery.
Journal of Neurosurgery:Spine, 20(1):75-82, 2014

2. Togami W., Sei A., Okada T., Taniwaki T., Fujimoto T., Nakamura T., Tahata S., Nakanishi Y., Mizuta H.
Effects of water-holding capability of the PVF sponge on the adhesion and differentiation of rat bone marrow stem cell culture.
Journal of Biomedical Materials Research Part A, 102(1):247-253, 2014

3. Aoi J., Endo M., Kadomatsu T., Miyata K., Ogata A., Horiguchi H., Odagiri H.,
Masuda T.,Fukushima S., Jinnin M., Hirakawa S., Sawa T., Akaike T., Ihn H., Oike Y.
Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress.
Molecular Cancer Research, 12(2):239-249, 2014 

4. Shinriki S., Jono H., Ueda M., Obayashi K., Nakamura T., Ota K., Ota T., Sueyoshi T., Guo J.,
Hayashi M., Hiraki A., Nakayama H., Yamashita S., Shinohara M. & Ando Y.
Stromal expression of neutrophil gelatinase-associated lipocalin correlates with poor differentiation and adverse prognosis in oral squamous cell carcinoma.
Histopathology, 64(3):356-364, 2014

5. Nakamura E., Okamoto N., Nishioka H., Karasugi T., Hirose J., and Miuzuta H.
The long-term outcomes of open-wedge osteotomy of the proximal tibia with hemicallotasis.
The Bone and Joint Journal, 96(4):467-472, 2014

6. Kamikawa M., Lei XF., Fujiwara Y., Nishitsuji K., Mizuta H., Takeya T., and
Sakashita N.
ACAT1-associated late endosomes/lysosomes significantly improve impaired intracellular cholesterol metabolism and survival of niemann-pick type c mice.
Acta Histochem Cytochem, 47(2):35-43, 2014

7. Nakamura E., Okamoto N., Nishioka H., Irie H and Mizuta H.
Development and validation of formulae to predict leg length following medial opening-wedge osteotomy of the proximal tibia with hemicallotasis.
The Knee, 21(4):815-820, 2014

8. Nakamura T., Okada T., Endo M., Kadomatsu T., Taniwaki T., Sei A., Odagiri H., Masuda T., Fujimoto T., Nakamura T., Oike Y., amd Mizuta H.
Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.
PLOS ONE, 9(1):e85542, 2014

9. Odagiri H., Kadomatsu T., Endo M., Masuda T., Morioka MS., Fukuhara S.,
Miyamoto T.,
Kobayashi E., Miyata K., Aoi J., Horiguchi H., NishimuraN., Terada K., Yakushiji T., Manabe I., Mochizuki N., Mizuta H., and Oike Y.
The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5 β1, p38 MAPK, and Matrix Metalloproteinases.
Science Signaling, 7(309):ra7, 2014

10. Uehara Y., Hirose J., Yamabe S., Okamoto N., Okada T., Oyadomari S., Mizuta H.
Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein.
Osteoarthritis Cartilage, 22(7):1007-1017, 2014

11. Okamoto N., Nakamura E., Nishioka H., Karasugi T., Okada T., Mizuta H.
In vivo kinematic comparison between mobile-bearing and fixed-bearing total knee arthroplasty during step-up activitiy
The Journal of Arthroplasty 29(12):2393-2396, 2014

12. Endo M., Yamamoto Y., Nakano M., Masuda T., Odagiri H., Horiguchi H., Miyata K., Kadomatsu K., Motokawa I., Okada S., Iwase H., and Oike Y.
Serum ANGPTL2 Levels Reflect Clinical Features of Breast Cancer Patients: Implications for The Pathogenesis of Breast Cancer Metastasis.
The International Journal of Biological Markers 29(3):239-245, 2014

13. Swain L., Wottawa M., Hillemann A., Beneke A., Odagiri H., Terada K., Endo M, Oike Y., Farhat K., Katschinski DM.
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions.
Journal of Leukocyte Biology 96(3):365-375, 2014

14. Uezono K., Ide J., Tokunaga T., Arimura H., Sakamoto H., Nakanishi Y., Mizuta H.
Effect of postoperative passive motion on rotator cuff reconstruction with acellular dermal matrix grafts in a rat model.
American Journal of Sports Medicine 42(8):1930-1938, 2014

15. Kikukawa k., Ide J., Kikuchi K., Morita M., Mizuta H., Ogata H.
Hypertrophic changes of the teres minor muscle in rotator cuff tears: Quantitative evaluation using magnetic resonance imaging.
Journal of Shoulder and Elbow Surgery 23(12):1800-1805, 2014

16. Horiguchi H., Endo M., Miyamoto Y., Sakamoto Y., Odagiri H., Masuda T., Kadomatsu T.,
Tanoue H., Motokawa I., Terada K., Morioka MS., Manabe I., Baba H., Oike Y.
Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling.
Cancer Science 105(12):1550-1559, 2014

17. Kotera, A., Irie, H., Iwashita, S., Taniguchi, J., Kasaoka, S., & Kinoshita, Y.
Comparison of the utility of the Pentax Airway Scope (AWS) with that of the conventional Macintosh laryngoscope during chest compression: is the AWS an easy‐to‐use device for a novice?.
Acute Medicine & Surgery 1(3), 163-169, 2014

18. Kotera, A., Irie, H., Iwashita, S., Taniguchi, J., Kasaoka, S., Sagishima, K., & Kinoshita, Y.
Electrocardiogram findings of patients with serum potassium levels of nearly 10.0 mmol/L: a report of two cases.
Acute Medicine & Surgery 1(4), 234-237. 2014

19. Nakajima M., Takahashi A., Tsuji T., Karasugi T., Baba H., Uchida K., Kawabata S., Okawa A., Shindo S., Takeuchi K., Taniguchi Y., Maeda S., Kashii M., Seichi A., Nakajima H., Kawaguchi Y., Fujibayashi S., Takahata M., Tanaka T., Watanabe K., Kida K., Kanchiku T., Ito Z., Mori K., Kaito T., Kobayashi S., Yamada K., Takahashi M., Chiba K., Matsumoto M., Furukawa K., Kubo M.,
Toyama Y:Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Ikegawa S.
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
Nature Genetics 46(9): 1012-1016, 2014.

20.Kotera A., Iwashita S., Irie H., Taniguchi J., Kasaoka S., & Kinoshita Y.
An analysis of the relationship between Glasgow Coma Scale score and plasma glucose level according to the severity of hypoglycemia.
Journal of Intensive Care 2:1, 2014


1.Taguchi K., Miyakawa T., Ohmura T., Horio M., Anraku Y., Okada T., Mizuta H., Saito H., Kawaguchi T.
A reduced linezolid dosage maintains favorable effi cacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureusinfected patient with renal insuffi ciency.
Scand J Infect Dis, 45(1):77-80, 2013

2.Araki D., Kuroda R., Matsumoto T., Nagamune K., Matsushita T., Kubo S., Oniki Y.,
Kurosaka M.
An analysis of surface profile for cylindrical osteochondral grafts of the knee quantitative evaluation using a three-dimensional laser scanner.
Knee Surg Sports Traumatol Arthrosc, 21(8):1794-1800, 2013

3.Takada K., Hirose J., Yamabe S., Uehara Y., Mizuta H.
Endoplasmic reticulum stress mediates nitric oxide-induced chondrocyte apoptosis.
Biomedical Reports, 1(2):315-319, 2013

4.Karasugi T., Nakajima M., Ikari K., Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments., Tsuji T., Matsumoto M., Chiba K., Uchida K., Kawaguchi Y., Mizuta H., Ogata N., Iwasaki M., Maeda S., Numasawa T., Abumi K., Kato T., Ozawa H., Taguchi T., Kaito T., Neo M., Yamazaki M., Tadokoro N., Yoshida M., Nakahara S., Endo K., Imagama S., Demura S., Sato K., Seichi A., Ichimura S., Watanabe M., Watanabe K., Nakamura Y., Mori K., Baba H., Toyama Y., Ikegawa S.
A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine.
J Bone Miner Metab, 31(2):136-143, 2013

5.Semba K., Araki K., Matsumoto K., Suda H., Ando T., Sei A., Mizuta H., Takagi K., Nakahara M., Muta M., Yamada G., Nakagata N., Iida A., Ikegawa S., Nakamura Y., Araki M., Abe K., Yamamura K.
Ectopic expression of ptf1a induces spinal defects, urogenital defects, and anorectal malformations in danforth’s short tail mice.
PLoS Genet, 9(2):1-17, 2013

6.Yamabe S., Hirose J., Uehara Y., Okada T., Okamoto N., Oka k., Taniwaki T., Mizuta H.
Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes.
FEBS J, 280(7):1617-1629, 2013

7.Uezono K., Ide J., Tokunaga T., Sakamoto H., Okamoto N., Mizuta H.
Effect of immobilization on rotator cuff reconstruction with acellular dermal matrix grafts in an animal model.
J Shoulder Elbow Surg, 22(9):1290-1297, 2013

8.Horlad H., Fujiwara Y., Takemura K., Ohnishi K., Ikeda T., Tsukamoto H., Mizuta H., Nishimura Y., Takeya M., Komohara Y.
Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells.
Mol Nutr Food Res, 57(6):1046-54, 2013

9.Nishioka H., Hirose J., Nakamura E., Okamoto N., Karasugi T., Taniwaki T., Okada T., Yamashita Y., Mizuta H.
Detecting ICRS grade l cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping.
European Journal Radiology, 82(9):1499-1505, 2013

10.Hirose J., Nishioka H., Okamoto N., Oniki Y., Nakamura E., Yamashita Y., Usuku K.,
Mizuta H.
Articular cartilage lesions increase early cartilage degeneration in knees treated by anterior cruciate ligament reconstruction T1ρ mapping evaluation and one-year follow-up.
The American Journal of Sports Medicine, 41(10):2353-2361, 2013

11.Haruta M., Tomita Y., Imamura Y., Matsumura K., Ikeda T., Takamatsu K., Nishimura Y., and Senju S.
Generation of a large number of functional dendritic cells from human monocytes expanded by forced expression of cMYC plus BMI1
Human Immunology, 74 (10):1400-1408, 2013

12.Song YQ., Karasugi T., Cheung KMC., Chiba K., Ho DWH., Miyake A., Kao PYP., Sze KL., Yee A., Takahashi A., Kawaguchi Y., Mikami Y., Matsumoto M., Togami D., Kanayama M., Shi D., Dai J., Jiang Q., Wu C., Tian W., Wang N., Leong JCY., Luk KKD., Yip SP., Cherny SS., Wang J.,
Mundlos S., Kelempisioti A., Eskola PJ., Männikkö M., Mäkelä P., Karppinen J., Järvelin MR., O’Reilly PF., Kubo M., Kimura T., Kubo T., Toyama Y., Mizuta H., Cheah KSEC., Tsunoda T., Sham P., Ikegawa S., and Chan D.
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.
The Journal of Clinical Investigation, 123(11):4909-4917, 2013


1. Nishioka H., Hirose J., Nakamura E., Oniki Y., Takada K., Yamashita Y., Mizuta H.
T1ρ and T2 mapping reveal the in vivo extracellular matrix of articular cartilage .
Journal of Magnetic Resonance Imaging, 35(1):147-155, 2012

2. Sueyoshi T., Jono H., Shinriki S., Ota K., Ota T., Tasaki M., Atsuyama E., Yakushiji T., Ueda M., Obayashi K., Mizuta H., Ando Y.
Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma.
Cancer Letters, 316(1):23-30, 2012

3. Endo M., Nakano M., Kadomatsu T., Fukuhara S., Kuroda H., Mikami S., Hato T., Aoi J., Horiguchi H., Miyata K., Odagiri H, Masuda T., Harada M., Horio H., Hishima T., Nomori H., Ito T., Yamamoto Y., Minami T., Okada S., Takahashi T., Mochizuki N., Iwase H., Oike Y.
Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.
Cancer Research, 72(7):1784-1794, 2012

4. Fujimoto T., Sei A., Taniwaki T., Okada T., Yakushiji T., Mizuta H.
Pedicle screw diameter selection for safe insertion in the thoracic spine.
European Journal of Orthopaedic Surgery & Traumatology, 22(5):351-356, 2012

5. Hirose J., Nishioka H., Nakamura E., Oniki Y., Yamashita Y., Mizuta H.
T1ρ and T2 mapping of the proximal tibiofibular joint in relation to aging and cartilage degeneration.
European Journal of Radiology, 81(10):2776-2782, 2012

6. Shiraishi D., Fujiwara Y., Komohara Y., Mizuta H., Takeya M.
Glucagon-like peptide-1(GLP-1)induces M2 polarization of human macrophages via STAT3 activation.
Biochemical and Biophysical Research Communications, 425(2):304-308, 2012


1. Matsumine A., Ueda T., Sugita T., Yazawa Y., Isu K., Kawai A., Abe S., Yakushiji T., Hiraga H., Sudo A., Uchida A.
Clinical outcomes of the KYOCERA physio hinge total knee system type III after the resection of a bone and soft tissue tumor of the distal part of the femur.
Journal Surgical Oncology, 103(3) : 257-263, 2011

2. Oka K., Yakushiji T., Sato H., Fujimoto T., Hirai T., Yamashita Y., Mizuta H.
Usefulness of diffusion-weighted imaging for differentiating between desmoid tumors and malignant soft tissue tumors.
Journal Magnetic Resonance Imaging, 33(1) : 189-193, 2011

3. Irie H., Kato T., Yakushiji T., Hirose J., Mizuta H.
Painful heterotopic pacinian corpuscle in the hand: a report of three cases.
Hand Surgery, 16(1) : 81-85, 2011

4. Ando T., Semba K., Suda H., Sei A., Mizuta H., Araki M., Abe K., Imai K., Nakagata N., Araki K., Yamamura K.
The floor plate is sufficient for development of the sclerotome and spine without the notochord.
Mechanisms of Development, 128(1-2) : 129-140, 2011

5. Watanabe A., Karasugi T., Sawai H., Naing BT., Ikegawa S., Orimo H., Shimada T.
Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasia in Japanese and effects of the mutation on heterozygous carriers.
Journal of Human Genetics, 56 (2) : 166-168, 2011

6. Suda H., Lee KJ., Semba K., Kyushima F., Ando T., Araki M., Araki K., Inomata Y., Yamamura K.
The Skt gene, required for anorectal development, is a candidate for a molecular marker of the cloacal plate.
Pediatric Surgery International, 27(3) : 269-273, 2011

7. Takahashi Y., Matsumoto M., Karasugi T., Watanabe K., Chiba K., Kawakami N., Tsuji T., Uno K., Suzuki T., Ito M., Sudo H., Minami S., Kotani T., Kono K., Yanagida H., Taneichi H., Takahashi A., Toyama Y., Ikegawa S.
Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes.
Journal of Orthopaedic Research, 29(6) : 834-837, 2011

8. Takahashi Y., Matsumoto M., Karasugi T., Watanabe K., Chiba K., Kawakami N., Tsuji T., Uno K., Suzuki T., Ito M., Sudo H., Minami S., Kotani T., Kono K., Yanagida H., Taneichi H., Takahashi A., Toyama Y., Ikegawa S.
Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population.
Journal of Orthopaedic Research, 29(7) : 1055-1078, 2011

9. Yano M., Watanabe K., Yamamoto T., Ikeda K., Senokuchi T., Lu M., Kadomatsu T., Tsukano H., Ikawa M., Okabe M., Yamaoka S., Okazaki T., Umehara H., Gotoh T., Song W., Node K., Taguchi R., Yamagata K., Oike Y.
Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice.
Journal of Biological Chemistry, 286(5) : 3992-4002, 2011

10. Hirose J., Yamabe S., Takada K., Okamoto N., Nagai R., Mizuta H.
Immunohistochemical distribution of advanced glycation end products (AGEs) in human osteoarthritic cartilage.
Acta Histochemica, 113(6) : 613-618, 2011

11. Dai J., Kim OH., Cho TJ., Miyake N., Song HR., Karasugi T., Sakazume S., Ikema M., Matsui Y., Nagai T., Matsumoto N., Ohashi H., Kamatani N., Nishimura G., Furuichi T., Takahashi A., Ikegawa S.
A founder mutation of CANT1 common in Korean and Japanese Desbuquois dysplasia.
Journal of Human Genetics, 56(5) : 398-400, 2011

12. Takada K., Hirose J., Semba K., Yamabe S., Oike Y., Gotoh T., Mizuta H.
Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage.
International Journal of Experimental Pathology, 92(4) : 232-242, 2011
International Journal of Experimental Pathology, 92(4) : 232-242, 2011

13. Sueyoshi T., Ueda M., Jono H., Irie H., Sei A., Ide J., Ando Y., Mizuta H.
Wild-type transthyretin-derived amyloidosis in various ligaments and tendons.
Human Pathology, 42(9) : 1259-1264, 2011

14. Okamoto N., Breslauer L., Hedley AK., Mizuta H., Banks SA.
In vivo knee kinematics in patients with bilateral total knee arthroplasty of 2 designs.
Journal of Arthroplasty, 26(6) : 914-918, 2011

15. Tanaka A., Nakamura E., Okamoto N., Banks SA., Mizuta H.
Three-dimensional kinematics during deep-flexion kneeling in mobile-bearing total knee arthroplasty.
The Knee, 18(6) : 412-416, 2011

16. Sueyoshi T., Ueda M., Sei A., Misumi Y., Oshima T., Yamashita T., Obayashi K., Shinriki S., Jono H., Shono M., Ando Y., Mizuta H.
Spinal multifocal amyloidosis derived from wild-type transthyretin. .
Amyloid, 18 (3):165-168, 2011

17.Kudo S., Mizuta H., Takagi K., Hiraki Y.
Cartilaginous repair of full-thickness articular cartilage defect is induced by the intermittent activation of PTH/PTHrP signaling.
Osteoarthritis and Cartilage, 19(7):886-894, 2011

18.Sanderson J., Nakanishi Y., Murayama N., Nishimura T., Ishi T., Mizuta H., Higaki H.
Polyetheretherketone in orthopedic plate design to facilitate fracture recovery.
Journal of Biomechanical Science and Engineering, 6(2):125-133, 2011

19.Aoi J., Endo M., Kadomatsu T., Miyata K., Nakano M., Horiguchi H., Ogata A., Odagiri H., Yano M., Araki K., Jinnin M., Ito T., Hirakawa S., Ihn H., Oike Y.
Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis.
Cancer Research, 71(24):7502-7512, 2011

20.Ide J, Nakamura E, Senba K, Mizuta H.
Surface roughness of retrived zirconia heads and polyethylene wear after cemented THA.
Science MED, 2:105-108, 2011.

21.Irie H., Kato T., Yakushiji T., Hirose J., Mizuta H.
Painful heterotopic pacinian corpuscle in the hand: a report of three cases.
Hand Surgery, 16(1):81-85, 2011.


1. Takemura K., Sakashita N., Fujiwara Y., Komohara Y., XiaoFeng Lei, Ohnishi K., Suzuki H., Kodama T., Mizuta H., Takeya M.
Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kB (RANK).
Biochemical and Biophysical Research Communications, 391(4): 1675-1680, 2010

2. Nakayama Y., Endo M., Tsukano H., Mori M., Oike Y., Gotoh T.
Molecular Mechanisms of the LPS-induced Non-apoptotic ER Stress-CHOP Pathway.
Journal of Biochemistry, 147(4): 471-483, 2010

3. Hirose J., Ide J., Yakushiji T., Abe Y., Nishida K., Maeda S., Anraku Y., Usuku K., Mizuta H.
Prediction of postoperative ambulatory status 1 year after hip fracture surgery.
Archives of Physical Medicine and Rehabilitation, 91(1): 67-72, 2010

4. Oka K., Yakushiji T., Sato H., Hirai T., Yamashita Y., Mizuta H.
The value of diffusion-weighted imaging for monitoring the chemotherapeuic response of osteosarcoma: a comparison between average apparent diffusion coefficient and minimum apparent diffusion coefficient.
Skeletal Radiology, 39(2): 141-146, 2010

5. Hirose J.
Clinical presentation and diagnosis of calcium deposition diseases (Review).
International Journal of Clinical Rheumatology, 5(1):117-128, 2010

6. Okada T., Tsukano H., Endo M., Tabata M., Miyata K., Kadomatsu T., Miyashita K., Semba K., Nakamura E., Tsukano M., Mizuta H., Oike Y.
Synoviocyte-Derived Angiopoietin-Like Protein 2 Contributes to Synovial Chronic Inflamma- tion in Rheumatoid Arthritis.
American Journal of Pathology, 176(5): 2309-2319, 2010

7. Okamoto N., Kuwahara K., Ohta K., Kitabatake M., Takagi K., Mizuta H., Kondo E., Sakaguchi N.
Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange.
Genes to Cells, 15(5): 471-483, 2010

8. Mizutamari M., Sei A., Tokiyoshi A., Fujimoto T., Taniwaki T., Togami W., Mizuta H.a H.
Corresponding scapular pain with the nerve root involved in cervical radiculopathy.
Journal of Orthopaedic Surgery, 18(3): 356-360, 2010

9. Jeong S., Kondo K., Ise M., Yamaga M., Asahi T., Ohgushi M., Kamoshita H., Nishimura N., Hara H., Yoshida K., Terasaki T., Toyota A., Kobayashi S.
The impact registered physicians created during participation as a rehabilitation specialist in acute rehabilitation wards.
International Journal of Stroke, 5: 292-293, 2010

10. Mori S., Hirose J., Yonemura K.
Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis.
Clinical Rheumatology, 29 (12): 1357-1366, 2010

11. Ota K., Fujimori H., Ueda M., Jono H., Shinriki S., Ota T., Sueyoshi T., Taura M., Taguma A., Kai H., Shinohara M., Ando Y.
Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma.
International Journal of Oncology, 37(4): 797-804, 2010

12. Ota T., Ota K., Jono H., Fujimori H., Ueda M., Shinriki S., Sueyoshi T., Shinohara M., Ando Y.
Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis.
Oral Oncology, 46(9): 657-61, 2010

13. Tsukano H., Gotoh T., Endo M., Miyata K., Tazume H., Kadomatsu T., Yano M., Iwawaki T., Kohno K., Araki K., Mizuta H., Oike Y.
The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosisin macrophages contributes to the instability of atherosclerotic plaques.
Arteriosclerosis Thrombosis and Vascular Biology, 30(10): 1925-1932, 2010


1. Maeda S., Kawai K., Koizumi M., Ide J., Tokiyoshi A., Mizuta H., Kodama K.
Morphological study of the communication between the musculocutaneous and median nerves.
Anatomical Science International, 84(1): 34-40, 2009

2. Maeda S., Kawai K., Koizumi M., Ide J., Tokiyoshi A., Mizuta H., Kodama K.
Morphological study, by teasing examination of the communication from the musculocutaneous to median nerves
Anatomical Science International, 84(1): 41-46, 2009

3. Mizutamari M., Sei A., Fujimoto T., Taniwaki T., Mizuta H.
L5 radiculopathy caused by a ganglion cyst of the posterior longitudinal ligament in a teenager.
The Spine Journal, 9(4): e11-e14, 2009

4. Ide J., Kikukawa K., Hirose J., Iyama K., Sakamoto H., Mizuta H.
Reconstruction of large rotator cuff tears with acellular dermal matrix graft in rats.
J. Shoulder Elbow Surg., 18(2): 288-295, 2009

5. Ide J., Kikukawa K., Hirose J., Iyama K., Sakamoto H., Fujimoto T., Mizuta H.
The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon.
J. Shoulder Elbow Surg , 18(3): 391-398, 2009

6. Ide J., Kikukawa K., Hirose J., Iyama K., Sakamoto H., Mizuta H.
The effects of fibroblast growth factor-2 on rotator cuff reconstruction with acellular dermal matrix grafts.
Arthroscopy , 25(6): 608-616, 2009

7. Sei A., Mizutamari M., Fujimoto T., Taniwaki T., Mizuta H.
Gas-filled intradural cysts of the lumbar spine and the possible pathogenesis.
Spine J., 9(7): e6-e8, 2009

8. Yakushiji T., Oka K., Sato H., Yorimitsu S., Fujimoto T., Yamashita Y., Mizuta H.
Characterization of chondroblastic osteosarcoma : gadolinium-enhanced versus diffusion-weighted MR imaging.
J. Magn. Reson. Imaging., 29(4): 895-900, 2009

9. Anraku Y., Mizuta H., Sei A., Kudo S., Nakamura E., Senba K., Hiraki Y.
Analyses of early events during chondrogenic repair in rat full-thickness articular cartilage defects.
J. Bone. Miner. Metab., 27(3): 272-286, 2009

10. Nakamura E., Banks S.A., Tanaka A., Sei A., Mizuta H.
Three-Dimensional Tibiofemoral Kinematics During Deep Flexion Kneeling in a Mobile-Bearing Total Knee Arthroplasty.
J. Arthroplasty, 24(7): 1120-1124, 2009

11. Karasugi T., Semba K., Hirose Y., Kelempisioti A., Nakajima M., Miyake A., Furuichi T., Kawaguchi Y., Mikami Y., Chiba K., Kamata M., Ozaki K., Takahashi A., Pirkka M., Karppinen J., Kimura T., Kubo T., Toyama Y., Yamamura K., Minna M., Mizuta H., Ikegawa S.
Association of the tag SNPs in the human SKT gene (KIAA1217) with lumbar disc herniation.
J. Bone. Miner. Res., 24(9): 1537-1543, 2009

12. Inomata Y., Fukushima M., Hara R., Takahashi E., Megumi Honjo M., Koga T., Kawaji T., Sato H., Takeya M., Sawamura T., Tanihara H.
Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice.
Invest. Ophthalmol. Vis. Sci., 50(8): 3970-3976, 2009

13. Hirose J., Ide J., Irie H., Kikukawa K., Mizuta H.
New Equations for Predicting Postoperative Risk in Patients with Hip Fracture.
Clin. Orthop. Relat. Res., 467(12): 3327-3333, 2009

14. Fujimoto T., Sei A., Taniwaki T., Mizutamari M., Mizuta H.
Unilateral Atlantoaxial Transpedicular Screw and Rod/Plate Fixation With Sublaminar Polyethylene Cable Fixation.
Neurosurgery Quarterly, 19(4): 235-240, 2009

15. Tabata M., Kadomatsu T., Fukuhara S., Miyata K., Ito Y., Endo M., Urano T., Zhu JH., Tsukano H., Tazume H., Kaikita K., Miyashita K., Iwawaki T., Shimabukuro M., Sakaguchi K., Ito T., Nakagata N., Yamada T., Katagiri H., Kasuga M., Ando Y., Ogawa H., Mochizuki N., Itoh H., Suda T., Oike Y.
Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance.
Cell Metabolism, 10(3): 178-188, 2009

16. Komohara Y., Takemura K., XiaoFeng Lei., Sakashita N., Suzuki H., Kodama T., Takeya M.
Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages.
Cancer Sci., 100(11): 2160-2166, 2009


1. Chen H., Li Z., Haruna K., Li Z., Li Z, Semba K, Araki M, Yamamura K, Araki K.
Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene.
Biochemical and Biophysical Research Communications, 365(4): 636-642, 2008

2. Fujimoto T., Sei A., Kurihara N., Mizuta H.
Traumatic Dislocation of the Atlanto-Occipital Joint With Subluxation of the Atlanto-Axial Joint : A Case Report of Survival in an Adult.
Jpn. J. Joint Dis, 27(1): 81-86, 2008

3. Hirose Y., Chiba K., Karasugi T., Nakajima M., Kawaguchi Y., Mikami Y., Furuich T., Mio F., Miyake A., Miyamoto T., Ozaki K., Takahashi A., Mizuta H., Kubo T., Kimura T., Tanaka T., Toyama Y., Ikegawa S.
A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar disc herniation.
Am. J. Hum. Genet., 82(5): 1122-1129, 2008

4. Ide J., Tokiyoshi A., Hirose J., Mizuta H.
An anatomical study of the subscapularis insertion to the humerus: The subscapularis footprint.
Arthroscopy, 24(7): 749-753, 2008

5. Hirose J., Mizuta H., Ide J., Nomura K.
Evaluation of Estimation of Physiologic Ability and Surgical Stress (E-PASS) to predict the postoperative risk for hip fracture in elder patients.
Arch. Orthop. Trauma Surg, 128(12): 1447-1452, 2008

6. Anraku Y., Mizuta H., Sei A., Kudo S., Nakamura E., Senba K., Takagi K., Hiraki Y.
The chondrogenic repair response of undifferentiated mesenchymal cells in rat full-thickness articular cartilage defects.
Osteoarthritis Cartilage, 16(8): 961-964, 2008

7. Sato H., Kiyota E., Terasaki Y., Sawamura T., Takagi K., Mizuta H., Takeya M.
Expression and Localization of Lectin-like Oxidized Low-Density Lipoprotein Receptor-1(LOX-1) in MUrine and Human Placentas.
Journal of Histochemistry and Cytochemistry, 56(8): 773-784, 2008

8. Oka K., Yakushiji T., Sato H., Yorimitsu S., Hayashida Y., Yamashita Y., Mizuta H.
The Ability of Diffusion-Weighted Imaging for the Differential Diagnosis between Chronic Expanding Hematomas and Malignant Soft Tissue Tumors.
Journal of Magnetic Resonance Imaging, 28(5): 1195-1200, 2008

9. Hirose J., Mizuta H., Ide J., Nakamura E., Takada K.
E-PASS for Predicting Postoperative Risk with Hip Fracture: A Multicenter Study.
Clinical Orthopaedics and Related Research, 466(11): 2833-2841, 2008

10. Kitamoto Y., Nakamura E., Kudo S., Tokunaga H., Murakami E., Noguchi K., Imamura T.
Thrombin in synovial fluid as a marker of synovial inflammation: a definite measurement by ELISA and correlation with VEGF.
Clin. Chim. Acta, 398(1-2): 159-160, 2008


1. Honma S., Tokiyoshi A., Katsushi K., Koizumi K., Kodama K.
Preureteric inferior vena cava with possible rudiment of the proper inferior vena cava
Ann. Anat., 189(2):191-195, 2007

2. Numata K., Kubo M., Watanabe H., Takagi K., Mizuta H., Okada S., Kunkel S. L., Ito T., Matsukawa A.
Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity.
J. Immunol., 178(6):3777-3785, 2007

3. Ishii I., Mizuta H., Sei A., Hirose J., Kudo S., Hiraki Y.
Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.
J. Bone Joint. Surg. (Br), 89(5):693-700, 2007

4. Mehta JL., Sanada N., Chen J., Hu CP., Dandapat A., Sugawara F., Inoue K., Takeya M., Kawase Y., Jishage K., Suzuki H., Satoh H., Schnackenberg L., Beger R., Hermonat PL., Thomas M., Sawamura T.
Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
Circ. Res., 100(11):1634-1642, 2007

5. Ide J., Tokiyoshi A., Hirose J., Mizuta H.
Arthroscopic repair of traumatic combined rotator cuff tears involving the subscapularis tendon.Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
J. Bone Joint Surg. (Am), 89(11):2378-2388, 2007

6. Higo S., Koizumi M., Kawai K., Honma S., Tokiyoshi A., Tamamaki N., Kodama K.
Anomaly with no right ventral root at the seventh cervical segment in humans: gross anatomical and neuroanatomical study.
Anat. Sci. Int., 82(3): 133-138, 2007


1. Kawai K., Koizumi M., Honma S., Tokiyoshi A., Kodama K.
A case of nonrotation of the midgut with a middle mesenteric artery.
Ann.Anat., 188(1):13-17, 2006

2. Kawai K., Yoshinaga K., Koizumi M., Honma S., Tokiyoshi A., Kodama K.
A middle meningeal artery which arises from the internal carotid artery in which the first branchial artery participates.
Ann. Anat., 188(1):33-38, 2006

3. Honma S., Kawai K., Koizumi M., Tokiyoshi A., Kodama K.
The deep axillary artery.
Anat. Sci. Int., 81(1):29-33, 2006

4. Semba K., Araki K., Li Z., Matsumoto K., Suzuki M., Nakagata N., Takagi K., Takeya M., Yoshinobu K., Araki M., Imai K., Abe K., Yamamura K.
A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc.
Genetics, 172(1):445-456, 2006

5. Hayashida Y., Hirai T., Yakushiji T., Katahira K., Shimomura O., Imuta M., Nakaura T., Utsunomiya D., Awai K., Yamashita Y.
Evaluation of diffusion-weighted imaging for the differential diagnosis of poorly contrast-enhanced and T2-prolonged bone masses: Initial experience.
J. Magn. Reson. Imaging, 23(3):377-382, 2006

6. Horikawa T., Komohara Y., Kiyota E., Terasaki Y., Takagi K., Takeya M.
Detection of guinea pig macrophages by a new CD68 monoclonal antibody, PM-1K.
J. Molecular. His., 37(1):15-25, 2006

7. Mizuta H., Kudo S., Nakamura E., Takagi K., Hiraki Y.
Expression of the PTH/PTHrP receptor in chondrogenic cells during the repair of full-thickness defects of articular cartilage.
Osteoarthr. Cartilage., 14(9):944-952, 2006

8. Komohara Y., Hirahara J., Horikawa T., Kawamura K., Kiyota E., Sakashita N., Araki N., Takeya M.
AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype.
J .Histochem. Cytochem., 54(7):763-771, 2006

9. Yamashita T., Inui S., Maeda K., Hua D.R., Takagi K., Fukunaga K., Sakaguchi N.
Regulation of CaMKII by α4/PP2Ac contributes to learning and memory.
Brain. Res., 1082(1):1-10, 2006

10. Hayashida Y., Yakushiji T., Awai K., Katahira K., Nakayama Y., Shimomura O., Kitajima M.,
Hirai T., Yamashita Y., Mizuta H.
Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: initial results.
Eur. Radiol., 16(12):2637-2643, 2006

11. Asami Y., Kawai K., Kanoh T., Koizumi M., Honma S., Tokiyoshi A., Kodama K.
Double innervation of the anterior belly of the digastric muscle.
Anat. Sci. Int., 81(2):130-133, 2006

12. Watanabe H., Kubo M., Numata K., Takagi K., Mizuta H., Seiji O., Ito T, Matsukawa A.
Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis.
J. Immunol., 177(12):8650-8657, 2006


1. Matsukawa A., Kudo S., Maeda T., Numata K., Watanabe H., Takeda K., Akira S., Ito T.
Stat3 in resident macrophages as a repressor protein of inflammatory response.
J. Immunol., 175(5):3354-3359, 2005

2. Kawatani Y., Igarashi H., Matsui T., Kuwahara K., Fujimura S., Okamoto N., Takagi K., Sakaguchi N.
Cutting edge: double-stranded DNA breaks in the IgV region gene were detected at lower frequency in affinity-maturation impeded GANP-/- Mice.
J. Immunol., 175(9):5615-1618, 2005

3. Oniki Y., Kato T., Irie H., Mizuta H., Takagi K.
Diabetes with hyperlipidemia: a risk factor for developing joint contractures secondary to immobility in rat knee joints?
J. Orthop.Sci., 10(2):221-226, 2005

4. Ide J., Maeda S., Takagi K.
Sports activity after arthroscopic superior labral repair using suture anchors in overhead-throwing athletes.
Am. J. Sports. Med., 33(4):507-514, 2005

5. Ide J., Maeda S., Takagi K.
A comparison of arthroscopic and open rotator cuff repair.
Arthroscopy, 21(9):1090-1098, 2005

6. Ide J., Maeda S., Takagi K.
Arthroscopic transtendon repair of partial-thickness articular-side tears of the rotator cuff: anatomical and clinical study.
Am. J. Sports. Med., 33(11):1672-1679, 2005

7. Ohgushi M., Ifuku H., Ito S., Ogawa H.
Response properties of neurons to sucrose in the reward phase and the areal distribution in the monkey fronto-operculuro-insular and prefrontal cortices during a taste discrimination GO/NOGO task.
Neurosci. Res., 51(3):253-263, 2005

8. Taniwaki T., Haruna K., Nakamura H., Sekimoto T., Oike Y., Imaizumi T., Saito F., Muta M., Soejima Y., Utoh A., Nakagata N., Araki M., Yamamura K., Araki K.
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-βgeo cassette.
Develop. Growth. Differ., 47(3):163-172, 2005

9. Yamashita T., Inui S., Maeda K., Hua D.R., Takagi K., Sakaguchi N.
The heterodimer of α4 and PP2Ac is associated with S6 kinase1 in B cells.
Biochem. Biop. Res. Co., 330(2):439-445, 2005

10. Inoue T., Nakamura T., Ikeda T., Takagi K.
Effect of extracellular matrix protein on the rate of proteoglycan synthesis in rabbit intervertebral disc cells.
J. Spinal. Disord. Tech., 18(1):52-57, 2005

11. Sugiuchi H., Ando Y., Manabe M., Nakamura E., Mizuta H., Nagata S., Okabe H.
Measurement of total and differential white blood cell counts in synovial fluid by means of an automated hematology analyzer.
J. Lab. Clin. Med., 146(1):36-42, 2005


1. Ide J., Maeda S., Takagi K.
Normal variations of the glenohumeral ligament complex: an anatomical study for arthroscopic Bankart repair.
Arthroscopy, 20(2):164-168, 2004

2. Ide J., Maeda S., Takagi K.
Arthroscopic Bankart repair using suture anchors in athletes: patient selection and postoperative sports activity.
Am. J. Sports. Med., 32(8):1899-1905, 2004

3. Ide J., Takagi K.
Early and long-term results of arthroscopic treatment for shoulder stiffness.
J. Shoulder. Elbow. Surg., 13(2):174-179, 2004

4. Irie H., Kato T., Ikebe K., Tsuchida T., Oniki Y., Takagi K.
Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model.
J. Surg. Res., 120(2):312-319, 2004

5. Iwamoto K., Miyamoto T., Sawatani Y., Hosogane N., Hamaguchi I., Takami M., Nomiyama K., Takagi K., Suda T.
Dimer formation of nuclear factor kB induces incomplete osteoclast formation.
Biochem. Bioph. Res. Co., 325(1):229-234, 2004

6. Nitta Y., Yoshida K., Satoh K., Senba K., Nakagata N., Peters J., Cattanach B.M.
Spontaneous and radiation-induced leukemogenesis of the mouse small eye mutant, Pax6(Sey3H).
J. Radiat. Res., 45(2):245-251, 2004

7. Tokiyoshi A., Koizumi M., Kawai K., Honma S., Takagi K., Kodama K.
Scalenus muscles in macaque monkeys.
Anat. Sci. Int., 79(1):32-42, 2004

8. Watanabe H., Numata K., Ito T., Takagi K., Matsukawa A.
Innate immune eesponse in TH1- and TH2- dominant mouse strains.
Shock, 22(5):460-466, 2004

9. Nakamura E., Mizuta H., Kadota M., Katahira K., Kudo S., Takagi K.
Three-dimensional computed tomography evaluation of semitendinosus harvest after anterior cruciate ligament reconstruction.
Arthroscopy, 20(4):360-365, 2004

10. Mizuta H., Kudo S., Nakamura E., Otsuka Y., Takagi K., Hiraki Y.
Active proliferation of mesenchymal cells prior to the chondrogenic repair response in rabbit full-thickness defects of articular cartilage.
Osteoarthr. Cartilage., 12(7):586-596, 2004

11. Galligan C.L., Matsuyama W., Matsukawa A., Mizuta H., Hodge D.R., Howard O.M.Z., Yoshimura T.
Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.
Arth. Rheum., 50(6):1806-1814, 2004

12. Chuma H., Mizuta H., Kudo S., Takagi K., Hiraki Y.
One day exposure to FGF-2 was sufficient for the regenerative repair of full-thickness defects of articular cartilage in rabbits.
Osteoarthr. Cartilage., 12(10):834-842, 2004

13. Mizuta H., Nakamura E., Kudo S., Maeda T., Takagi K.
Greater frequency of distraction accelerates bone formation in open-wedge proximal tibial osteotomy with hemicallotasis.
Acta. Orthop. Scand., 75(5):588-593, 2004